Autologous ADSC therapy for femoral head necrosis

2020-03-18 12:06:55 admin
Autologous ADSC therapy for femoral head necrosis 

Mr. Zhao, 75 years old with a history of comminuted fracture of the right hip joint 

Mr. Zhao, comminuted fracture of the right hip joint, underwent the nonunion after surgical fixation. 

Intervention treatment of autologous ADSCs is as follows:

In June 2018, 100ml fat was extracted, and 300 million autologous ADSCs were obtained in collaboration with Magellan Lab after 6 weeks of Australian TGA certification. Australian licensed medical experts developed an exclusive anti-aging program for him with 300 million autologous ADSCs. 100 million autologous ADSCs were divided into 4 times for intravenous transplantation within one year to perform systemic function intervention for anti-aging repair; the rest 200 million autologous ADSCs were divided into 4 injections into the cavity on the right hip joint within one years. One year later, his bone was completely healed, and Mr. Zhao stood up again. He feels that the allomeric function is rejuvenated, and the immunity enhanced. He is full of energy in daily life, and impressed by the magical effects of autologous ADSC intervention. 

Application effect and mechanism of autologous ADSC therapy on femoral head necrosis 

1. Stem cell immunoregulation: inflammatory molecules released from femoral head necrosis can lead to unbearable hip joint pain, and accelerate the process of femoral head necrosis. Stem cells can initiate immunoregulatory pathways, and inhibit inflammatory responses for anti-inflammatory and analgesic. 

2. Stem cell osteogenic differentiation: stem cell therapy repairs necrotic parts of the femoral head. Osteogenic differentiation of the stem cells in the transplant can be achieved by virtue of self-proliferation and multi-directional differentiation abilities, to increase bone density, prevent osteoporosis, and significantly improve bone damage. 

3. Stem cell vessel regeneration: stem cells can secrete related cytokines (such as growth factors). It improves the microenvironment around the femoral head, promotes peripheral blood vessel regeneration, increases blood supply, accelerates blood circulation, and promotes rapid repair and union of necrotic parts of the femoral head. 

4. Stem cell bone nerve repair: Stem cells can also rebuild neural circuits in bone tissue. In the early-to-mid stages of femoral head necrosis, the sympathetic nerve fibrosis in the bone is relatively mild. Stem cells can repair nerve cell function, regulate bone metabolism and endosseous microcirculation, and restore hip joint function. 

In addition, stem cell therapy can also relieve the advanced femoral head necrosis. Since the femoral head has collapsed and deformed in the late stage, the joint space in the femoral head area will become narrower, and the ischemia more serious, which definitely increases the difficulty in diagnosis and treatment. Therefore, the mechanism of femoral head necrosis should be further understood, and the diagnosis and treatment of femoral head necrosis with stem cell intervention improved. 

Stem cell therapy has an obvious curative effect on femoral head necrosis, thus better restoring hip joint function to a certain extent, and improving blood circulation in necrosis areas of the femoral head. All the evidence can prove that autologous ADSC therapy serves as the safest and most effective method. 


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